{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(6)"],"submitter":["Markel G"],"pubmed_abstract":["<h4>Background</h4>Francisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection.<h4>Methodology/principal findings</h4>Here we provide evidence for the involvement of IL-17A in host defense to inhalational tularemia, using a mouse model of intranasal infection with the Live Vaccine Strain (LVS). We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary gammadelta and Th17 cells. The peak of IL-17A production appears early during sub-lethal infection, it precedes the peak of immune activation and the nadir of the disease, and then subside"],"journal":["PloS one"],"pagination":["e11176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2887844"],"repository":["biostudies-literature"],"pubmed_title":["The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis."],"pmcid":["PMC2887844"],"pubmed_authors":["Cohen O","Zahavy E","Markel G","Cohen H","Bar-Haim E","Velan B","Shafferman A"],"additional_accession":[]},"is_claimable":false,"name":"The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.","description":"<h4>Background</h4>Francisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection.<h4>Methodology/principal findings</h4>Here we provide evidence for the involvement of IL-17A in host defense to inhalational tularemia, using a mouse model of intranasal infection with the Live Vaccine Strain (LVS). We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary gammadelta and Th17 cells. The peak of IL-17A production appears early during sub-lethal infection, it precedes the peak of immune activation and the nadir of the disease, and then subside","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2025-04-26T19:02:03.599Z","creation":"2019-03-26T23:08:46Z"},"accession":"S-EPMC2887844","cross_references":{"pubmed":["20585449"],"doi":["10.1371/journal.pone.0011176"]}}