{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Simon DM"],"funding":["NHLBI NIH HHS"],"pagination":["69"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2889874"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<h4>Background</h4>Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARgamma deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand the impact of airspace enlargement in conditionally targeted mice upon the physio-mechanical properties of the lung.<h4>Methods</h4>We measured elastic recoil and its determinants, including tissue structure and surface forces. We measured alveolar number using radial alveolar counts, and airspace sizes and their distribution using computer-assisted morphometry.<h4>Results</h4>Air vs. saline-filled pressure volume profiles demon"],"journal":["Respiratory research"],"pubmed_title":["PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution."],"pmcid":["PMC2889874"],"funding_grant_id":["HL071885"],"pubmed_authors":["Ingenito EP","Starcher BC","Mariani TJ","Tsai LW","Simon DM"],"additional_accession":[]},"is_claimable":false,"name":"PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution.","description":"<h4>Background</h4>Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARgamma deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand the impact of airspace enlargement in conditionally targeted mice upon the physio-mechanical properties of the lung.<h4>Methods</h4>We measured elastic recoil and its determinants, including tissue structure and surface forces. We measured alveolar number using radial alveolar counts, and airspace sizes and their distribution using computer-assisted morphometry.<h4>Results</h4>Air vs. saline-filled pressure volume profiles demon","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2026-07-15T10:08:42.45Z","creation":"2026-07-03T03:12:05.41Z"},"accession":"S-EPMC2889874","cross_references":{"pubmed":["20525205"],"doi":["10.1186/1465-9921-11-69"]}}