{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taffe MA"],"funding":["NIDA NIH HHS","NIAAA NIH HHS"],"pagination":["11104-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2890755"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(24)"],"pubmed_abstract":["Binge alcohol consumption in adolescents is increasing, and studies in animal models show that adolescence is a period of high vulnerability to brain insults. The purpose of the present study was to determine the deleterious effects of binge alcohol on hippocampal neurogenesis in adolescent nonhuman primates. Heavy binge alcohol consumption over 11 mo dramatically and persistently decreased hippocampal proliferation and neurogenesis. Combinatorial analysis revealed distinct, actively dividing hippocampal neural progenitor cell types in the subgranular zone of the dentate gyrus that were in transition from stem-like radial glia-like cells (type 1) to immature transiently amplifying neuroblasts (type 2a, type 2b, and type 3), suggesting the evolutionary conservation of milestones of neuronal"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates."],"pmcid":["PMC2890755"],"funding_grant_id":["R21 AA013972-01A1","P50 AA006420","R01 AA016807","AA06420","R01 AA016807-02","R21 AA013972","AA013972","R21 AA013972-02","R21 AA013972-03","DA022473","R01 AA016807-01A2","K01 DA022473","AA016807"],"pubmed_authors":["Crawford EF","Edwards S","Taffe MA","Kotzebue RW","Crean RD","Mandyam CD"],"additional_accession":[]},"is_claimable":false,"name":"Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates.","description":"Binge alcohol consumption in adolescents is increasing, and studies in animal models show that adolescence is a period of high vulnerability to brain insults. The purpose of the present study was to determine the deleterious effects of binge alcohol on hippocampal neurogenesis in adolescent nonhuman primates. Heavy binge alcohol consumption over 11 mo dramatically and persistently decreased hippocampal proliferation and neurogenesis. Combinatorial analysis revealed distinct, actively dividing hippocampal neural progenitor cell types in the subgranular zone of the dentate gyrus that were in transition from stem-like radial glia-like cells (type 1) to immature transiently amplifying neuroblasts (type 2a, type 2b, and type 3), suggesting the evolutionary conservation of milestones of neuronal","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2025-04-26T11:30:57.507Z","creation":"2019-03-27T00:31:48Z"},"accession":"S-EPMC2890755","cross_references":{"pubmed":["20534463"],"doi":["10.1073/pnas.0912810107"]}}