biostudies-literatureWalker LMNIAID NIH HHS358-66https://www.ebi.ac.uk/biostudies/studies/S-EPMC2891291biostudies-literatureUnknown22(3)Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.Current opinion in immunologyRational antibody-based HIV-1 vaccine design: current approaches and future directions.PMC2891291R01 AI033292-18R01 AI033292R37 AI055332R37 AI055332-07Walker LMBurton DRfalseRational antibody-based HIV-1 vaccine design: current approaches and future directions.Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.2010-01-01T00:00:00Z2010 Jun2021-02-19T07:59:17Z2019-06-06T22:11:00ZS-EPMC28912912029919410.1016/j.coi.2010.02.012