{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Venturini L"],"pubmed_abstract":["<h4>Background</h4>Most cancers maintain telomeres by activating telomerase but a significant minority, mainly of mesenchymal origin, utilize an alternative lengthening of telomeres (ALT) mechanism.<h4>Methods</h4>In this study we comparatively analyzed the prognostic relevance of ALT in a monoinstitutional series of 85 liposarcoma patients as a function of the marker (ALT-associated promyelocytic leukemia bodies (APB) versus heterogeneous telomeres) used to classify the tumor.<h4>Results</h4>Independently of the detection approach, ALT proved to be a prognostic discriminant of increased mortality, although the prognostic relevance of the two markers appeared at different follow-up intervals (at 10 years for APB and 15 years for telomeres).<h4>Conclusions</h4>Overall, we confirmed ALT as a"],"journal":["BMC cancer"],"pagination":["254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2894794"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis."],"pmcid":["PMC2894794"],"pubmed_authors":["Motta R","Venturini L","Gronchi A","Daidone M","Zaffaroni N"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis.","description":"<h4>Background</h4>Most cancers maintain telomeres by activating telomerase but a significant minority, mainly of mesenchymal origin, utilize an alternative lengthening of telomeres (ALT) mechanism.<h4>Methods</h4>In this study we comparatively analyzed the prognostic relevance of ALT in a monoinstitutional series of 85 liposarcoma patients as a function of the marker (ALT-associated promyelocytic leukemia bodies (APB) versus heterogeneous telomeres) used to classify the tumor.<h4>Results</h4>Independently of the detection approach, ALT proved to be a prognostic discriminant of increased mortality, although the prognostic relevance of the two markers appeared at different follow-up intervals (at 10 years for APB and 15 years for telomeres).<h4>Conclusions</h4>Overall, we confirmed ALT as a","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2025-04-19T09:51:57.127Z","creation":"2019-03-27T00:32:00Z"},"accession":"S-EPMC2894794","cross_references":{"pubmed":["20525266"],"doi":["10.1186/1471-2407-10-254"]}}