biostudies-literatureWelch EJNIDDK NIH HHSHoward Hughes Medical InstituteNHLBI NIH HHS86-97https://www.ebi.ac.uk/biostudies/studies/S-EPMC2895371biostudies-literatureUnknown10(2)A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one cellular location to the next. This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes.Molecular interventionsNetworking with AKAPs: context-dependent regulation of anchored enzymes.PMC2895371P01DK54441P01 DK054441DK54441R01 HL088366Scott JDWelch EJJones BWfalseNetworking with AKAPs: context-dependent regulation of anchored enzymes.A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one cellular location to the next. This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes.2010-01-01T00:00:00Z2010 Apr2025-04-05T13:40:25.991Z2019-06-06T22:11:53ZS-EPMC28953712036836910.1124/mi.10.2.6