{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Epstein JH"],"funding":["NIAID NIH HHS","FIC NIH HHS"],"pagination":["e1000972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2895649"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades."],"journal":["PLoS pathogens"],"pubmed_title":["Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh."],"pmcid":["PMC2895649"],"funding_grant_id":["AI57158","R01 AI079231","K08 AI067549","U54 AI057158","K08AI067549","AI070411","AI079231","R01 TW005869","U01 AI070411"],"pubmed_authors":["Verdugo D","Luby SP","Quan PL","Lipkin WI","Jabado O","Epstein JH","Hutchison SK","Egholm M","Daszak P","Ali Khan S","Briese T","Hossain MJ","Street C","Conlan S"],"additional_accession":[]},"is_claimable":false,"name":"Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh.","description":"Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2021-02-19T18:37:47Z","creation":"2019-03-27T00:32:02Z"},"accession":"S-EPMC2895649","cross_references":{"pubmed":["20617167"],"doi":["10.1371/journal.ppat.1000972"]}}