{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan TG"],"funding":["Intramural NIH HHS","NIAID NIH HHS"],"pagination":["3977-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2895808"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(23)"],"pubmed_abstract":["Toxoplasma gondii is an intracellular parasite that causes severe neurologic and ocular disease in immune-compromised and congenitally infected individuals. There is no vaccine protective against human toxoplasmosis. Herein, immunization of L(d) mice with HF10 (HPGSVNEFDF) with palmitic acid moieties or a monophosphoryl lipid A derivative elicited potent IFN-gamma production from L(d)-restricted CD8(+) T cells in vitro and protected mice. CD8(+) T cell peptide epitopes from T. gondii dense granule proteins GRA 3, 6, 7, and Sag 1, immunogenic in humans for HLA-A02(+), HLA-A03(+), and HLA-B07(+) cells were identified. Since peptide repertoire presented by MHC class I molecules to CD8(+) T cells is shaped by endoplasmic reticulum-associated aminopeptidase (ERAAP), polymorphisms in the human E"],"journal":["Vaccine"],"pubmed_title":["Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans."],"pmcid":["PMC2895808"],"funding_grant_id":["R01 AI027530","R01 AI071319","U01 AI77887","U01 AI077887"],"pubmed_authors":["McLeod R","Tan TG","Sette A","Mui E","Witola WH","Cong H","Maewal A","Montpetit A","Muench SP","Grigg ME","Sidney J","Alexander J"],"additional_accession":[]},"is_claimable":false,"name":"Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.","description":"Toxoplasma gondii is an intracellular parasite that causes severe neurologic and ocular disease in immune-compromised and congenitally infected individuals. There is no vaccine protective against human toxoplasmosis. Herein, immunization of L(d) mice with HF10 (HPGSVNEFDF) with palmitic acid moieties or a monophosphoryl lipid A derivative elicited potent IFN-gamma production from L(d)-restricted CD8(+) T cells in vitro and protected mice. CD8(+) T cell peptide epitopes from T. gondii dense granule proteins GRA 3, 6, 7, and Sag 1, immunogenic in humans for HLA-A02(+), HLA-A03(+), and HLA-B07(+) cells were identified. Since peptide repertoire presented by MHC class I molecules to CD8(+) T cells is shaped by endoplasmic reticulum-associated aminopeptidase (ERAAP), polymorphisms in the human E","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2026-04-16T21:21:49.22Z","creation":"2026-04-07T14:17:43.879Z"},"accession":"S-EPMC2895808","cross_references":{"pubmed":["20347630"],"doi":["10.1016/j.vaccine.2010.03.028"]}}