{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rampersaud E"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["329-39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2896493"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(4)"],"pubmed_abstract":["The role of parent-of-origin effects (POE) in the etiology of complex diseases such as type 2 diabetes (T2DM) and obesity is currently of intense interest, but still largely unclear. POE are transmittable genetic effects whereby the expression of the phenotype in the offspring depends upon whether the transmission originated from the mother or father. In mammals, POE can be caused by genetic imprinting, intrauterine effects, or maternally inherited mitochondrial genes. In this paper, we describe the different mechanisms underlying POE, characterize known examples of POE in rare forms of diabetes, and review the evidence from linkage and association studies for POE in T2DM and obesity. Finally, we summarize some of the new and established statistical and experimental approaches commonly use"],"journal":["Current diabetes reviews"],"pubmed_title":["Investigating parent of origin effects in studies of type 2 diabetes and obesity."],"pmcid":["PMC2896493"],"funding_grant_id":["R01-HL088119","R01 DK054261","R01 DK054261-09","R01-DK073490","R01 DK073490-05","T32 HL072751","R01-AR43351","R01 HL088119","R01 HL088119-04","R01 AR043351","P30 DK072488","R01-DK54261","R01 AR043351-11","T32 HL007024","R01 DK073490"],"pubmed_authors":["Naj AC","Pollin TI","Rampersaud E","Mitchell BD"],"additional_accession":[]},"is_claimable":false,"name":"Investigating parent of origin effects in studies of type 2 diabetes and obesity.","description":"The role of parent-of-origin effects (POE) in the etiology of complex diseases such as type 2 diabetes (T2DM) and obesity is currently of intense interest, but still largely unclear. POE are transmittable genetic effects whereby the expression of the phenotype in the offspring depends upon whether the transmission originated from the mother or father. In mammals, POE can be caused by genetic imprinting, intrauterine effects, or maternally inherited mitochondrial genes. In this paper, we describe the different mechanisms underlying POE, characterize known examples of POE in rare forms of diabetes, and review the evidence from linkage and association studies for POE in T2DM and obesity. Finally, we summarize some of the new and established statistical and experimental approaches commonly use","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Nov","modification":"2025-04-05T10:56:45.912Z","creation":"2019-06-06T22:12:12Z"},"accession":"S-EPMC2896493","cross_references":{"pubmed":["18991601"],"doi":["10.2174/157339908786241179"]}}