{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Krebs AR"],"pubmed_abstract":["The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes."],"journal":["EMBO reports"],"pagination":["541-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2897115"],"repository":["biostudies-literature"],"pubmed_title":["ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes."],"pmcid":["PMC2897115"],"pubmed_authors":["Karmodiya K","Krebs AR","Chang AC","Chang NC","Tora L","Demmers J"],"additional_accession":[]},"is_claimable":false,"name":"ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.","description":"The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2026-05-02T15:11:55.932Z","creation":"2019-03-27T00:32:07Z"},"accession":"S-EPMC2897115","cross_references":{"pubmed":["20508642"],"doi":["10.1038/embor.2010.75"]}}