biostudies-literatureUnknown11(7)Krebs ARThe Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.EMBO reports541-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC2897115biostudies-literatureATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.PMC2897115Karmodiya KKrebs ARChang ACChang NCTora LDemmers JfalseATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.2010-01-01T00:00:00Z2010 Jul2026-05-02T15:11:55.932Z2019-03-27T00:32:07ZS-EPMC28971152050864210.1038/embor.2010.75