{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Revil T"],"funding":["Canadian Institutes of Health Research"],"pubmed_abstract":["<h4>Background</h4>Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isolated examples. High throughput technologies now allow us to study genome-wide alternative splicing during mouse development.<h4>Results</h4>A genome-wide analysis of alternative isoform expression in embryonic day 8.5, 9.5 and 11.5 mouse embryos and placenta was carried out using a splicing-sensitive exon microarray. We show that alternative splicing and isoform expression is frequent across developmental stages and tissues, and is comparable in frequency to the variation in whole-transcr"],"journal":["BMC genomics"],"pagination":["399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2898759"],"repository":["biostudies-literature"],"pubmed_title":["Alternative splicing is frequent during early embryonic development in mouse."],"pmcid":["PMC2898759"],"pubmed_authors":["Revil T","Dias C","Gaffney D","Jerome-Majewska LA","Majewski J"],"additional_accession":[]},"is_claimable":false,"name":"Alternative splicing is frequent during early embryonic development in mouse.","description":"<h4>Background</h4>Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isolated examples. High throughput technologies now allow us to study genome-wide alternative splicing during mouse development.<h4>Results</h4>A genome-wide analysis of alternative isoform expression in embryonic day 8.5, 9.5 and 11.5 mouse embryos and placenta was carried out using a splicing-sensitive exon microarray. We show that alternative splicing and isoform expression is frequent across developmental stages and tissues, and is comparable in frequency to the variation in whole-transcr","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2026-04-15T03:14:18.412Z","creation":"2026-04-15T03:09:32.31Z"},"accession":"S-EPMC2898759","cross_references":{"pubmed":["20573213"],"doi":["10.1186/1471-2164-11-399"]}}