{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mahapatra CT"],"funding":["NCRR NIH HHS","NIEHS NIH HHS","NIGMS NIH HHS"],"pagination":["225-38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2902855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(1)"],"pubmed_abstract":["Methylmercury (MeHg) is a ubiquitous environmental contaminant that preferentially targets the developing nervous system. Variable outcomes of prenatal MeHg exposure within a population point to a genetic component that regulates MeHg toxicity. We therefore sought to identify fundamental MeHg tolerance genes using the Drosophila model for genetic and molecular dissection of a MeHg tolerance trait. We observe autosomal dominance in a MeHg tolerance trait (development on MeHg food) in both wild-derived and laboratory-selected MeHg-tolerant strains of flies. We performed whole-genome transcript profiling of larval brains of tolerant (laboratory selected) and nontolerant (control) strains in the presence and absence of MeHg stress. Pairwise transcriptome comparisons of four conditions (+/-sele"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pubmed_title":["Identification of methylmercury tolerance gene candidates in Drosophila."],"pmcid":["PMC2902855"],"funding_grant_id":["R01 ES015550-01","R01 GM067862","R01 ES015550","P20 RR016462","R01 ES015550-03","R01-ES015550","R01 ES015550-02","R01 ES015550-05","R01 ES015550-04"],"pubmed_authors":["Bond J","Mahapatra CT","Rand MD","Rand DM"],"additional_accession":[]},"is_claimable":false,"name":"Identification of methylmercury tolerance gene candidates in Drosophila.","description":"Methylmercury (MeHg) is a ubiquitous environmental contaminant that preferentially targets the developing nervous system. Variable outcomes of prenatal MeHg exposure within a population point to a genetic component that regulates MeHg toxicity. We therefore sought to identify fundamental MeHg tolerance genes using the Drosophila model for genetic and molecular dissection of a MeHg tolerance trait. We observe autosomal dominance in a MeHg tolerance trait (development on MeHg food) in both wild-derived and laboratory-selected MeHg-tolerant strains of flies. We performed whole-genome transcript profiling of larval brains of tolerant (laboratory selected) and nontolerant (control) strains in the presence and absence of MeHg stress. Pairwise transcriptome comparisons of four conditions (+/-sele","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2025-04-19T04:12:24.706Z","creation":"2019-03-27T00:32:23Z"},"accession":"S-EPMC2902855","cross_references":{"pubmed":["20375079"],"doi":["10.1093/toxsci/kfq097"]}}