biostudies-literatureCorneveaux JJNIA NIH HHSMedical Research CouncilAlzheimers Research UKNINDS NIH HHS3295-301https://www.ebi.ac.uk/biostudies/studies/S-EPMC2908469biostudies-literatureUnknown19(16)In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1, as well as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.Human molecular geneticsAssociation of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.PMC2908469R01 AG034504R01 AG015819ART-PG2010-1P30 AG019610R01 NS059873U01 AG016976G0400074K08 AG034290G0701075G0900652G0502157Meechoovet HBChewning KHardy JFrost DGerber JDBenson HLMyers AJCraig DWChibnik LBEngel AReiman EMDe Jager PLChen KSingleton ABVan Keuren-Jensen KRDunckley TShulman JMCorneveaux JJRamirez MO'Reilly SBennett DAAllen ANVilla SEHeward CLee WNalls MAPruzin JJHuentelman MJfalseAssociation of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1, as well as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.2010-01-01T00:00:00Z2010 Aug2020-11-19T08:56:21Z2019-03-27T00:32:37ZS-EPMC29084692053474110.1093/hmg/ddq221