{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Constantino J"],"funding":["NHLBI NIH HHS","National Institutes of Health"],"pagination":["953-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2908526"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(7)"],"pubmed_abstract":["<h4>Background</h4>After near-defibrillation threshold (DFT) shocks from an implantable cardioverter-defibrillator (ICD), the first postshock activation that leads to defibrillation failure arises focally after an isoelectric window (IW). The mechanisms underlying the IW remain incompletely understood.<h4>Objective</h4>The goal of this study was to provide mechanistic insight into the origins of postshock activations and IW after ICD shocks, and to link shock outcome to the preshock state of the ventricles. We hypothesized that the nonuniform ICD field results in the formation of an intramural excitable area (tunnel) only in the left ventricular (LV) free wall, through which both pre-existing and new shock-induced wavefronts propagate during the IW.<h4>Methods</h4>Simulations were conducte"],"journal":["Heart rhythm"],"pubmed_title":["Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric window."],"pmcid":["PMC2908526"],"funding_grant_id":["R01-HL082729","R01 HL063195-05","R01 HL082729-04","R01-HL067322","R01 HL082729","R01 HL063195","R01 HL067322"],"pubmed_authors":["Constantino J","Long Y","Ashihara T","Trayanova NA"],"additional_accession":[]},"is_claimable":false,"name":"Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric window.","description":"<h4>Background</h4>After near-defibrillation threshold (DFT) shocks from an implantable cardioverter-defibrillator (ICD), the first postshock activation that leads to defibrillation failure arises focally after an isoelectric window (IW). The mechanisms underlying the IW remain incompletely understood.<h4>Objective</h4>The goal of this study was to provide mechanistic insight into the origins of postshock activations and IW after ICD shocks, and to link shock outcome to the preshock state of the ventricles. We hypothesized that the nonuniform ICD field results in the formation of an intramural excitable area (tunnel) only in the left ventricular (LV) free wall, through which both pre-existing and new shock-induced wavefronts propagate during the IW.<h4>Methods</h4>Simulations were conducte","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2025-04-03T23:54:12.362Z","creation":"2019-03-26T23:04:44Z"},"accession":"S-EPMC2908526","cross_references":{"pubmed":["20348028"],"doi":["10.1016/j.hrthm.2010.03.026"]}}