{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sha W"],"funding":["Mead Johnson Nutrition","NIDDK NIH HHS","NCRR NIH HHS","NIEHS NIH HHS","National Institutes of Health","Egg Nutrition Center"],"pagination":["2962-75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2909293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(8)"],"pubmed_abstract":["Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate diet. We determined whether metabolomic profiling of plasma at baseline could predict whether humans will develop liver dysfunction when deprived of dietary choline. Fifty-three participants were fed a diet containing 550 mg choline/70 kg/d for 10 d and then fed < 50 mg choline/70 kg/d for up to 42 d. Participants who developed organ dysfunction on this diet were repleted with a choline-adequate diet for > or = 3 d. Plasma samples, obtained at baseline, end of depletion, and end of repletion, w"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline."],"pmcid":["PMC2909293"],"funding_grant_id":["DK56350","P30 DK056350","RR00046","DK55865","P30 ES010126","M01 RR000046","R01 DK055865"],"pubmed_authors":["Milburn MV","Berger A","Sha W","da Costa KA","Jia W","Zeisel SH","Lawton KA","Fischer LM"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline.","description":"Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate diet. We determined whether metabolomic profiling of plasma at baseline could predict whether humans will develop liver dysfunction when deprived of dietary choline. Fifty-three participants were fed a diet containing 550 mg choline/70 kg/d for 10 d and then fed < 50 mg choline/70 kg/d for up to 42 d. Participants who developed organ dysfunction on this diet were repleted with a choline-adequate diet for > or = 3 d. Plasma samples, obtained at baseline, end of depletion, and end of repletion, w","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Aug","modification":"2026-05-01T21:02:42.399Z","creation":"2026-04-07T17:18:55.509Z"},"accession":"S-EPMC2909293","cross_references":{"pubmed":["20371621"],"doi":["10.1096/fj.09-154054"]}}