{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holmes RS"],"funding":["NCRR NIH HHS","NHLBI NIH HHS"],"pagination":["217-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2917524"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(3)"],"pubmed_abstract":["At least six families of mammalian acid lipases (E.C. 3.1.1.-) catalyse the hydrolysis of triglycerides in the body, designated as LIPA (lysosomal), LIPF (gastric), LIPJ (testis) and LIPK, LIPM and LIPN (epidermal), which belong to the AB hydrolase superfamily. In this study, in silico methods were used to predict the amino acid sequences, secondary and tertiary structures, and gene locations for acid lipase genes and encoded proteins using data from several mammalian genome projects. Mammalian acid lipase genes were located within a gene cluster for each of the 8 mammalian genomes examined, including human (Homo sapiens), chimpanzee (Pons troglodytes), rhesus monkey (Macacca mulatta), mouse (Mus musculus), rat (Rattus norvegicus), cow (Bos taurus), horse (Equus caballus) and dog (Canis fa"],"journal":["Comparative biochemistry and physiology. Part D, Genomics & proteomics"],"pubmed_title":["Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo)."],"pmcid":["PMC2917524"],"funding_grant_id":["P51 RR013986","P01 HL028972","C06 RR017515","C06 RR013556","C06 RR015456","1 C06 RR13556","1 C06 RR017515","1 C06 RR15456"],"pubmed_authors":["VandeBerg JL","Holmes RS","Cox LA"],"additional_accession":[]},"is_claimable":false,"name":"Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo).","description":"At least six families of mammalian acid lipases (E.C. 3.1.1.-) catalyse the hydrolysis of triglycerides in the body, designated as LIPA (lysosomal), LIPF (gastric), LIPJ (testis) and LIPK, LIPM and LIPN (epidermal), which belong to the AB hydrolase superfamily. In this study, in silico methods were used to predict the amino acid sequences, secondary and tertiary structures, and gene locations for acid lipase genes and encoded proteins using data from several mammalian genome projects. Mammalian acid lipase genes were located within a gene cluster for each of the 8 mammalian genomes examined, including human (Homo sapiens), chimpanzee (Pons troglodytes), rhesus monkey (Macacca mulatta), mouse (Mus musculus), rat (Rattus norvegicus), cow (Bos taurus), horse (Equus caballus) and dog (Canis fa","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Sep","modification":"2026-05-03T15:07:00.971Z","creation":"2026-04-07T19:19:31.41Z"},"accession":"S-EPMC2917524","cross_references":{"pubmed":["20598663"],"doi":["10.1016/j.cbd.2010.05.004"]}}