biostudies-literatureUnknown5(8)Weaver EA<h4>Background</h4>Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats and has been used as a model for the study of human immunodeficiency virus (HIV). A feature of HIV and FIV infection is the continually increasing divergence among viral isolates between different individuals, as well as within the same individuals.<h4>Methodology/principal findings</h4>The goal of this study was to determine the phylogenetic patterns of viral isolates obtained within the United States (U.S.) by focusing on the variable, V3-V4, region of the FIV envelope gene.<h4>Conclusions/significance</h4>Data indicate that FIV, from within the U.S., localize to four viral clades, A, B, C, and F. Also shown is the geographic isolation of strains where clade A and clade B are found predominately on the west coast; however, clade B is also found throughout the U.S. and represents the predominant clade. This study presents a complete and conclusive analysis of FIV isolates from within the U.S. and may be used as the essential basis for the development of an effective multi-clade vaccine.PloS onee12004https://www.ebi.ac.uk/biostudies/studies/S-EPMC2918497biostudies-literatureA detailed phylogenetic analysis of FIV in the United States.PMC2918497Weaver EAfalseA detailed phylogenetic analysis of FIV in the United States.<h4>Background</h4>Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats and has been used as a model for the study of human immunodeficiency virus (HIV). A feature of HIV and FIV infection is the continually increasing divergence among viral isolates between different individuals, as well as within the same individuals.<h4>Methodology/principal findings</h4>The goal of this study was to determine the phylogenetic patterns of viral isolates obtained within the United States (U.S.) by focusing on the variable, V3-V4, region of the FIV envelope gene.<h4>Conclusions/significance</h4>Data indicate that FIV, from within the U.S., localize to four viral clades, A, B, C, and F. Also shown is the geographic isolation of strains where clade A and clade B are found predominately on the west coast; however, clade B is also found throughout the U.S. and represents the predominant clade. This study presents a complete and conclusive analysis of FIV isolates from within the U.S. and may be used as the essential basis for the development of an effective multi-clade vaccine.2010-01-01T00:00:00Z2010 Aug2021-02-21T09:08:40Z2019-03-26T23:08:52ZS-EPMC29184972071125310.1371/journal.pone.0012004