{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["177(3)"],"submitter":["LaBranche TP"],"pubmed_abstract":["In this study, a chronic yet synchronized version of the K/BxN mouse, the KRN-cell transfer model (KRN-CTM), was developed and extensively characterized. The transfer of purified splenic KRN T cells into T cell-deficient B6.TCR.Calpha(-/-)H-2(b/g7) mice induced anti-glucose 6-phosphate isomerase antibody-dependent chronic arthritis in 100% of the mice with uniform onset of disease 7 days after T cell transfer. Cellular infiltrations were assessed by whole-ankle transcript microarray, cytokine and chemokine levels, and microscopic and immunohistochemical analyses 7 through 42 days after T cell transfer. Transcripts identified an influx of monocytes/macrophages and neutrophils into the ankles and identified temporal progression of cartilage damage and bone resorption. In both serum and ankle"],"journal":["The American journal of pathology"],"pagination":["1388-96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2928971"],"repository":["biostudies-literature"],"pubmed_title":["Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse."],"pmcid":["PMC2928971"],"pubmed_authors":["Hickman-Brecks CL","Barve RA","Jesson MI","Happa FA","Meyer DM","Storer CE","Allen PM","LaBranche TP","Weiss DJ","Minnerly JC","Racz JL","Shevlin KM"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse.","description":"In this study, a chronic yet synchronized version of the K/BxN mouse, the KRN-cell transfer model (KRN-CTM), was developed and extensively characterized. The transfer of purified splenic KRN T cells into T cell-deficient B6.TCR.Calpha(-/-)H-2(b/g7) mice induced anti-glucose 6-phosphate isomerase antibody-dependent chronic arthritis in 100% of the mice with uniform onset of disease 7 days after T cell transfer. Cellular infiltrations were assessed by whole-ankle transcript microarray, cytokine and chemokine levels, and microscopic and immunohistochemical analyses 7 through 42 days after T cell transfer. Transcripts identified an influx of monocytes/macrophages and neutrophils into the ankles and identified temporal progression of cartilage damage and bone resorption. In both serum and ankle","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Sep","modification":"2025-04-04T09:43:47.768Z","creation":"2019-06-06T22:18:59Z"},"accession":"S-EPMC2928971","cross_references":{"pubmed":["20696780"],"doi":["10.2353/ajpath.2010.100195"]}}