{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rohrer JD"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["603-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2931766"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(7)"],"pubmed_abstract":["<h4>Background</h4>Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved.<h4>Methods</h4>We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agramma"],"journal":["Neurology"],"pubmed_title":["Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis."],"pmcid":["PMC2931766"],"funding_grant_id":["NF-SI-0508-10123","G0401247"],"pubmed_authors":["Warren JD","Rohrer JD","Rossor MN"],"additional_accession":[]},"is_claimable":false,"name":"Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.","description":"<h4>Background</h4>Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved.<h4>Methods</h4>We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agramma","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Aug","modification":"2025-04-22T05:12:50.093Z","creation":"2019-03-27T00:33:46Z"},"accession":"S-EPMC2931766","cross_references":{"pubmed":["20713949"],"doi":["10.1212/WNL.0b013e3181ed9c6b","10.1212/wnl.0b013e3181ed9c6b"]}}