biostudies-literatureRohrer JDMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome Trust603-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC2931766biostudies-literatureUnknown75(7)<h4>Background</h4>Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved.<h4>Methods</h4>We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agrammaNeurologySyndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.PMC2931766NF-SI-0508-10123G0401247Warren JDRohrer JDRossor MNfalseSyndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.<h4>Background</h4>Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved.<h4>Methods</h4>We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agramma2010-01-01T00:00:00Z2010 Aug2025-04-22T05:12:50.093Z2019-03-27T00:33:46ZS-EPMC29317662071394910.1212/WNL.0b013e3181ed9c6b10.1212/wnl.0b013e3181ed9c6b