biostudies-literature00530Adams MDNCRR NIH HHSNIAID NIH HHS3569-77https://www.ebi.ac.uk/biostudies/studies/S-EPMC2934971biostudies-literatureUnknown54(9)Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed differences in antimicrobial susceptibility. Resistance genes associated with insertion sequences, plasmids, and a chromosomal resistance gene island all showed variability. The highly dynamic resistance gene repertoire suggests rapid evolution of drug resistance.Antimicrobial agents and chemotherapyGenomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii.PMC2934971UL1 RR024989R01-AI072219R01 AI072219Adams MDMolyneaux NDChan ERBonomo RA53falseGenomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii.Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed differences in antimicrobial susceptibility. Resistance genes associated with insertion sequences, plasmids, and a chromosomal resistance gene island all showed variability. The highly dynamic resistance gene repertoire suggests rapid evolution of drug resistance.2010-01-01T00:00:00Z2010 Sep2024-12-03T20:58:50.298Z2021-02-19T22:04:55ZS-EPMC29349712053022810.1128/aac.00057-1010.1128/AAC.00057-10