{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["107(36)"],"submitter":["Arimoto K"],"pubmed_abstract":["The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA helicase RIG-I and/or MDA5. According to recent studies, the NF-kappaB essential modulator (NEMO, also called IKKgamma) is crucial for this virus-induced antiviral response. However, the precise roles of signal activation by NEMO adaptor have not been elucidated. Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23). Virus-induced IRF3 and N"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["15856-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2936632"],"repository":["biostudies-literature"],"pubmed_title":["Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense."],"pmcid":["PMC2936632"],"pubmed_authors":["Takeuchi O","Saeki Y","Murakami Y","Funami K","Shimotohno K","Arimoto K","Akira S","Okawa K","Tanaka K"],"additional_accession":[]},"is_claimable":false,"name":"Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.","description":"The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA helicase RIG-I and/or MDA5. According to recent studies, the NF-kappaB essential modulator (NEMO, also called IKKgamma) is crucial for this virus-induced antiviral response. However, the precise roles of signal activation by NEMO adaptor have not been elucidated. Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23). Virus-induced IRF3 and N","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Sep","modification":"2025-04-19T09:51:47.945Z","creation":"2019-03-27T00:33:56Z"},"accession":"S-EPMC2936632","cross_references":{"pubmed":["20724660"],"doi":["10.1073/pnas.1004621107"]}}