biostudies-literatureShi XNSF MRINational Institutes of HealthNIAMS NIH HHS2460-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC2937097biostudies-literatureUnknown43(13)Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading directiJournal of biomechanicsType and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions.PMC2937097R01 AR052008AR051376DBI-0420980R01 AR052008-05R01 AR052008-05S1AR052008R01 AR051376Guo XENiebur GLWang XShi XLiu XSfalseType and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions.Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using individual trabeculae segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading directi2010-01-01T00:00:00Z2010 Sep2025-04-19T09:49:16.244Z2019-03-27T00:33:58ZS-EPMC29370972055428210.1016/j.jbiomech.2010.05.032