{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raison CL"],"funding":["Schering-Plough","Centocor","National Center for Research Resources","NCATS NIH HHS","GlaxoSmithKline","NCRR NIH HHS","NIMH NIH HHS","NHLBI NIH HHS","National Institutes of Health","Clinical and Translational Science Award Program","General Clinical Research Center Program"],"pagination":["942-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2937202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["68(10)"],"pubmed_abstract":["<h4>Background</h4>Consequences of chronic exposure to cytokines of the innate immune system on sleep in humans and the association of cytokine-induced sleep alterations with behavior, motor performance, and cortisol secretion are unknown.<h4>Methods</h4>Thirty-one patients with hepatitis C without pre-existing sleep disorders underwent nighttime polysomnography, daytime multiple sleep latency testing, behavioral assessments, neuropsychological testing, and serial blood sampling at baseline and after ∼12 weeks of either treatment with the innate immune cytokine interferon (IFN)-alpha (n = 19) or no treatment (n = 12). Fatigue and sleepiness were assessed using the Multidimensional Fatigue Inventory and Epworth Sleepiness Scale.<h4>Results</h4>Interferon-alpha administration led to signific"],"journal":["Biological psychiatry"],"pubmed_title":["Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol."],"pmcid":["PMC2937202"],"funding_grant_id":["R01 HL073921-05","R01 HL073921-04","R01 MH083746","UL1 TR000454","K23 MH064619","R01 MH075102","R01 HL073921-03","R01 HL073921-02","R01 HL073921","R01 MH060723","R01 MH070553","UL1 RR025008","M01 RR000039","R01 MH067990-01A1","R01 MH067990","R01 HL073921-01A1","R01 MH075102-01A1","R01 MH067990-03","R01 MH067990-02","R01 MH067990-05","T32 MH020018","R01 MH067990-04","M01 RR0039","K05 MH069124","K05 MH069124-01","R01 MH075102-03","R01 MH075102-02","R01 MH075102-05","K05 MH069124-04","K05 MH069124-05","R01 MH075102-04","K05 MH069124-02","K05 MH069124-03"],"pubmed_authors":["Woolwine BJ","Rye DB","Bautista BM","Raison CL","Spivey JR","Miller AH","Vogt GJ"],"additional_accession":[]},"is_claimable":false,"name":"Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol.","description":"<h4>Background</h4>Consequences of chronic exposure to cytokines of the innate immune system on sleep in humans and the association of cytokine-induced sleep alterations with behavior, motor performance, and cortisol secretion are unknown.<h4>Methods</h4>Thirty-one patients with hepatitis C without pre-existing sleep disorders underwent nighttime polysomnography, daytime multiple sleep latency testing, behavioral assessments, neuropsychological testing, and serial blood sampling at baseline and after ∼12 weeks of either treatment with the innate immune cytokine interferon (IFN)-alpha (n = 19) or no treatment (n = 12). Fatigue and sleepiness were assessed using the Multidimensional Fatigue Inventory and Epworth Sleepiness Scale.<h4>Results</h4>Interferon-alpha administration led to signific","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Nov","modification":"2025-04-19T09:49:38.515Z","creation":"2019-03-27T00:33:58Z"},"accession":"S-EPMC2937202","cross_references":{"pubmed":["20537611"],"doi":["10.1016/j.biopsych.2010.04.019"]}}