biostudies-literatureRaison CLSchering-PloughCentocorNational Center for Research ResourcesNCATS NIH HHSGlaxoSmithKlineNCRR NIH HHSNIMH NIH HHSNHLBI NIH HHSNational Institutes of HealthClinical and Translational Science Award ProgramGeneral Clinical Research Center Program942-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC2937202biostudies-literatureUnknown68(10)<h4>Background</h4>Consequences of chronic exposure to cytokines of the innate immune system on sleep in humans and the association of cytokine-induced sleep alterations with behavior, motor performance, and cortisol secretion are unknown.<h4>Methods</h4>Thirty-one patients with hepatitis C without pre-existing sleep disorders underwent nighttime polysomnography, daytime multiple sleep latency testing, behavioral assessments, neuropsychological testing, and serial blood sampling at baseline and after ∼12 weeks of either treatment with the innate immune cytokine interferon (IFN)-alpha (n = 19) or no treatment (n = 12). Fatigue and sleepiness were assessed using the Multidimensional Fatigue Inventory and Epworth Sleepiness Scale.<h4>Results</h4>Interferon-alpha administration led to significBiological psychiatryChronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol.PMC2937202R01 HL073921-05R01 HL073921-04R01 MH083746UL1 TR000454K23 MH064619R01 MH075102R01 HL073921-03R01 HL073921-02R01 HL073921R01 MH060723R01 MH070553UL1 RR025008M01 RR000039R01 MH067990-01A1R01 MH067990R01 HL073921-01A1R01 MH075102-01A1R01 MH067990-03R01 MH067990-02R01 MH067990-05T32 MH020018R01 MH067990-04M01 RR0039K05 MH069124K05 MH069124-01R01 MH075102-03R01 MH075102-02R01 MH075102-05K05 MH069124-04K05 MH069124-05R01 MH075102-04K05 MH069124-02K05 MH069124-03Woolwine BJRye DBBautista BMRaison CLSpivey JRMiller AHVogt GJfalseChronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol.<h4>Background</h4>Consequences of chronic exposure to cytokines of the innate immune system on sleep in humans and the association of cytokine-induced sleep alterations with behavior, motor performance, and cortisol secretion are unknown.<h4>Methods</h4>Thirty-one patients with hepatitis C without pre-existing sleep disorders underwent nighttime polysomnography, daytime multiple sleep latency testing, behavioral assessments, neuropsychological testing, and serial blood sampling at baseline and after ∼12 weeks of either treatment with the innate immune cytokine interferon (IFN)-alpha (n = 19) or no treatment (n = 12). Fatigue and sleepiness were assessed using the Multidimensional Fatigue Inventory and Epworth Sleepiness Scale.<h4>Results</h4>Interferon-alpha administration led to signific2010-01-01T00:00:00Z2010 Nov2025-04-19T09:49:38.515Z2019-03-27T00:33:58ZS-EPMC29372022053761110.1016/j.biopsych.2010.04.019