{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stengel A"],"funding":["NIDDK NIH HHS"],"pagination":["4224-35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2940496"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(9)"],"pubmed_abstract":["Somatostatin and octreotide injected into the brain have been reported to modulate food intake. However, little is known regarding the underlying mechanisms. The stable oligosomatostatin analog, des-AA(1,2,4,5,12,13)-[DTrp(8)]-somatostatin (ODT8-SST), like somatostatin, binds to all five somatostatin receptors (sst(1-5)). We characterized the effects of ODT8-SST injected intracerebroventricularly (i.c.v.) on food consumption and related mechanisms of action in freely fed rats. ODT8-SST (0.3 and 1 microg per rat, i.c.v.) injected during the light or dark phase induced an early onset (within 1 h) and long-lasting (4 h) increase in food intake in nonfasted rats. By contrast, i.p. injection (0.3-3 mg/kg) or i.c.v. injection of selective sst(1) or sst(4) agonists (1 microg per rat) had no effec"],"journal":["Endocrinology"],"pubmed_title":["Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats."],"pmcid":["PMC2940496"],"funding_grant_id":["DK-41301","P30 DK041301","R01 DK033061","R01 DK-33061"],"pubmed_authors":["Rivier J","Alsina-Fernandez J","Stengel A","Tache Y","Coskun T","Goebel M","Craft L","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats.","description":"Somatostatin and octreotide injected into the brain have been reported to modulate food intake. However, little is known regarding the underlying mechanisms. The stable oligosomatostatin analog, des-AA(1,2,4,5,12,13)-[DTrp(8)]-somatostatin (ODT8-SST), like somatostatin, binds to all five somatostatin receptors (sst(1-5)). We characterized the effects of ODT8-SST injected intracerebroventricularly (i.c.v.) on food consumption and related mechanisms of action in freely fed rats. ODT8-SST (0.3 and 1 microg per rat, i.c.v.) injected during the light or dark phase induced an early onset (within 1 h) and long-lasting (4 h) increase in food intake in nonfasted rats. By contrast, i.p. injection (0.3-3 mg/kg) or i.c.v. injection of selective sst(1) or sst(4) agonists (1 microg per rat) had no effec","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Sep","modification":"2025-04-05T12:23:47.145Z","creation":"2019-03-27T00:34:08Z"},"accession":"S-EPMC2940496","cross_references":{"pubmed":["20610566"],"doi":["10.1210/en.2010-0195"]}}