{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bovine Genome Sequencing and Analysis Consortium"],"funding":["NIDA NIH HHS","NHGRI NIH HHS","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["522-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2943200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["324(5926)"],"pubmed_abstract":["To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mam"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["The genome sequence of taurine cattle: a window to ruminant biology and evolution."],"pmcid":["PMC2943200"],"funding_grant_id":["U54 HG003273","BB/D524040/2","077198","P30 DA018310","BBS/B/13438","062023","BBS/B/13446"],"pubmed_authors":["Verschoor CP","Hastings N","Carroll JA","Stone RT","Kolbehdari D","Gibbs RA","Brinkman FS","Hakimov HA","Eyras E","De Donato M","Maruyama SR","Hitchens ME","Barris W","Salih H","Caetano AR","Taylor JF","Khalil SS","Dalrymple B","Taniguchi M","More DD","Gill CA","Jann O","Plass M","Elnitski L","Reymond A","Waterman RC","Astashyn A","Elsik CG","Lien S","Genini S","Boldt CR","Lahmers KK","Liu GE","Larkin DM","Schook L","Worley KC","Anatriello E","Lewin HA","Spurlock D","Waardenberg AJ","Biase FH","Kapetis D","Chrast J","Payne GM","Colley AJ","Rosenwald A","Raison JM","Memili E","Tellam RL","Eggen A","Lewis LR","Kokocinski F","Ruiz SJ","McKay SD","Lynn DJ","Keele JW","Lopez J","Bovine Genome Sequencing and Analysis Consortium","Marra MA","Morgan MB","Chiu R","Connelley T","Souvorov A","Adelson DL","Hines S","Chandrabose MM","Logan KM","Mazza R","Zhu B","Herzig CT","Williams JL","Sweedler JV","Liu YS","Antonarakis SE","Lee JC","Ellis SA","Welsh TH","Hlavina W","Patel BM","Yang MQ","Riggs PK","McWilliam S","Camara F","Maqbool NJ","Dovc P","Dao MD","Davis C","Iso-Touru T","Green RD","Chapin JE","Weikard R","Schmutz SM","Zhao FQ","Snelling WM","Li C","Rachagani S","Chen L","Henrichsen CN","Brown WC","Nandakumar HP","Hamernik DL","Ucla C","Skow LC","Steffen D","Hamilton C","Rodriguez-Osorio N","Abatepaulo AR","Curry S","Pant SD","Jhangiani SN","Graur D","Jiang H","Lemay DG","Stothard P","Sapojnikov V","Lutzow YS","Moore SS","Liu Y","Carvalho WA","Jensen K","Baldwin CL","Chacko E","Halgren R","Fritz K","Marques E","Chacko J","Buhay C","Donthu R","Molenaar AJ","Hiendleder SG","Guan L","Muzny DM","Moreno BT","Childers CP","Gilbert JG","Moore R","Schein JE","Hernandez M","Alioto T","Bennett GL","Fowler GR","Greaser ML","Eichler EE","Abbey CA","Okwuonu GO","Nogueira MF","Junier T","Moen C","Ingham A","Ranganathan S","Sodergren E","Shen L","Hart EA","Urbanski JM","Cervelatti EP","Wheeler TT","Goodell J","Zhang J","Leach R","Wheeler DA","Nazareth LV","Sugimoto Y","Vattathil S","Ermolaeva O","Dickens CM","German JB","Kent MP","Elhaik E","Chen HC","Edgar RC","Macneil MD","Lau LP","Santos IK","Cree A","Baxter R","Shen Y","White SN","McLean KL","Chitko-McKown CG","Poli MA","Bennett AK","Iivanainen A","Hu ZL","Solovyev V","Nicholas FW","Kappes SM","Kerr T","Martin WF","Grant JR","Dinh HH","Kovar CL","de Campos TA","Gabisi RA","Harhay GP","Chapple CE","Hadsell DL","Lee S","Kiryutin B","Reecy J","Egan A","Ren Y","Wunderlich KR","Qin X","Ahola V","Bahadue SM","Glass EJ","Santibanez J","Amadio AF","Cheng Y","Cheng Z","Brinkmeyer-Langford CL","Holt RA","Deobald H","Sherman L","McEwan JC","Casey T","Medrano JF","Muntean CT","Southey BR","Gerlach D","Herdandez J","Wilming LG","Whiteside MD","Jones SJ","Hobbs M","Pruitt K","Weinstock GM","Bradley DG","Fitzsimmons CJ","Reese JT","Roberts A","Williams RL","Olsaker I","Gladney CJ","Rincon G","Takasuga A","Green JA","Malinverni R","Nguyen NB","Jamis C","Romero NE","Brownstein MJ","Utsunomiya YT","Poslusny N","Kitts P","Wang Z","Garcia GR","Bell SN","Yang J","Kriventseva EV","Wright RA","Martins NF","Anzola JM","Almeida IG","Razpet A","Tammen I","Johnson AJ","Kapustin Y","Sabo A","Hagen DE","Maglott D","Landrum M","Womack J","Ratnakumar A","Lozado RJ","Pu LL","Schnabel RD","Rodriguez-Zas SL","Choi J","Guigo R","Kumar CG","Garcia JF","Alexander L","Eberlein A","Ward R","Wyss C","Franzin AM","Telugu BP","Ding Y","Warren JT","Walker A","Dugan-Rocha S","Sonstegard TS","Van Tassell CP","Joshi V","Aerts J","Holder M","Sando L","Wilczek-Boney K","de Oliveira CJ","Havlak P","Zdobnov EM","Matukumalli LK","Durbin KJ","Khatib H","Song H","Song J","Hume J","Kumar D","Seo S","Rijnkels M","Harrow JL","Smith T","Donohue KE","Searle SM","Devinoy E","Panzitta F","Pastor RC"],"additional_accession":[]},"is_claimable":false,"name":"The genome sequence of taurine cattle: a window to ruminant biology and evolution.","description":"To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mam","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Apr","modification":"2026-04-30T07:25:57.443Z","creation":"2019-03-27T00:34:14Z"},"accession":"S-EPMC2943200","cross_references":{"pubmed":["19390049"],"doi":["10.1126/science.1169588"]}}