{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Siddiki H"],"pubmed_abstract":["<h4>Introduction</h4>Dead-space fraction (Vd/Vt) has been shown to be a powerful predictor of mortality in acute lung injury (ALI) patients. The measurement of Vd/Vt is based on the analysis of expired CO2 which is not a part of standard practice thus limiting widespread clinical application of this method. The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables.<h4>Methods</h4>Secondary analysis of the original data from two prospective studies of ALI patients. Estimated Vd/Vt was calculated using the rearranged alveolar gas equation: Vd/Vt=1-[(0.86×VCO2est)/(VE×PaCO2)] where VCO2est is the estimated CO2 production calculated from the Harris Benedict equation, minute ventilation (VE) is obtained from the ventilator rate"],"journal":["Critical care (London, England)"],"pagination":["R141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2945122"],"repository":["biostudies-literature"],"pubmed_title":["Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials."],"pmcid":["PMC2945122"],"pubmed_authors":["Li G","Siddiki H","Kojicic M","Yilmaz M","Thompson TB","Hubmayr RD","Gajic O"],"additional_accession":[]},"is_claimable":false,"name":"Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials.","description":"<h4>Introduction</h4>Dead-space fraction (Vd/Vt) has been shown to be a powerful predictor of mortality in acute lung injury (ALI) patients. The measurement of Vd/Vt is based on the analysis of expired CO2 which is not a part of standard practice thus limiting widespread clinical application of this method. The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables.<h4>Methods</h4>Secondary analysis of the original data from two prospective studies of ALI patients. Estimated Vd/Vt was calculated using the rearranged alveolar gas equation: Vd/Vt=1-[(0.86×VCO2est)/(VE×PaCO2)] where VCO2est is the estimated CO2 production calculated from the Harris Benedict equation, minute ventilation (VE) is obtained from the ventilator rate","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010","modification":"2025-05-29T20:31:10.747Z","creation":"2025-05-29T20:31:10.747Z"},"accession":"S-EPMC2945122","cross_references":{"pubmed":["20670411"],"doi":["10.1186/cc9206"]}}