biostudies-literatureUnknown85(10)Schindewolf M<h4>Objective</h4>To determine the incidence and causes of skin reactions to the synthetic pentasaccharide fondaparinux.<h4>Patients and methods</h4>Patients who received prophylactic/therapeutic subcutaneous fondaparinux treatment for more than 7 days were prospectively examined for cutaneous adverse effects between September 1, 2008, and April 30, 2009. When indicated, other procedures, such as skin biopsy, allergy testing, and clinical/laboratory assessment for thrombosis and heparin-induced thrombocytopenia, were performed.<h4>Results</h4>Overall, 231 patients were enrolled. No patient developed typical delayed type IV hypersensitivity (DTH) erythematous skin lesions. However, one female patient experienced abdominal pruritus at sites of injection. Histology revealed a mild lymphohistiMayo Clinic proceedings913-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC2947963biostudies-literatureLow allergenic potential with fondaparinux: results of a prospective investigation.PMC2947963Hecking CLindhoff-Last EMarzi ISchindewolf MBoehncke WHGarbaraviciene JKroll HScheuermann JWolter MKaufmann RLudwig RJfalseLow allergenic potential with fondaparinux: results of a prospective investigation.<h4>Objective</h4>To determine the incidence and causes of skin reactions to the synthetic pentasaccharide fondaparinux.<h4>Patients and methods</h4>Patients who received prophylactic/therapeutic subcutaneous fondaparinux treatment for more than 7 days were prospectively examined for cutaneous adverse effects between September 1, 2008, and April 30, 2009. When indicated, other procedures, such as skin biopsy, allergy testing, and clinical/laboratory assessment for thrombosis and heparin-induced thrombocytopenia, were performed.<h4>Results</h4>Overall, 231 patients were enrolled. No patient developed typical delayed type IV hypersensitivity (DTH) erythematous skin lesions. However, one female patient experienced abdominal pruritus at sites of injection. Histology revealed a mild lymphohisti2010-01-01T00:00:00Z2010 Oct2025-04-05T13:40:54.68Z2019-03-27T00:34:30ZS-EPMC29479632084398310.4065/mcp.2010.0346