biostudies-literatureShaw PIntramural NIH HHS888-96https://www.ebi.ac.uk/biostudies/studies/S-EPMC2948210biostudies-literatureUnknown66(8)<h4>Context</h4>Just as typical development of anatomical asymmetries in the human brain has been linked with normal lateralization of motor and cognitive functions, disruption of asymmetry has been implicated in the pathogenesis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). No study has examined the development of cortical asymmetry using longitudinal neuroanatomical data.<h4>Objective</h4>To delineate the development of cortical asymmetry in children with and without ADHD.<h4>Design</h4>Longitudinal study.<h4>Setting</h4>Government Clinical Research Institute.<h4>Participants</h4>A total of 218 children with ADHD and 358 typically developing children, from whom 1133 neuroanatomical magnetic resonance images were acquired prospectively.<h4>Main oArchives of general psychiatryDevelopment of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder.PMC2948210ZIA MH002794-08ZIA MH002240-23Rabin CShaw PEvans ARapoport JLalonde FSharp WGiedd JNEckstrand KGreenstein DLepage CfalseDevelopment of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder.<h4>Context</h4>Just as typical development of anatomical asymmetries in the human brain has been linked with normal lateralization of motor and cognitive functions, disruption of asymmetry has been implicated in the pathogenesis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). No study has examined the development of cortical asymmetry using longitudinal neuroanatomical data.<h4>Objective</h4>To delineate the development of cortical asymmetry in children with and without ADHD.<h4>Design</h4>Longitudinal study.<h4>Setting</h4>Government Clinical Research Institute.<h4>Participants</h4>A total of 218 children with ADHD and 358 typically developing children, from whom 1133 neuroanatomical magnetic resonance images were acquired prospectively.<h4>Main o2009-01-01T00:00:00Z2009 Aug2025-04-19T09:52:23.673Z2019-03-27T00:10:23ZS-EPMC29482101965212810.1001/archgenpsychiatry.2009.103