{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dong X"],"funding":["NIDDK NIH HHS","PHS HHS"],"pagination":["1294-309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2948974"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(10)"],"pubmed_abstract":["Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. Depletion of dendritic cells by clodronate pretreatment showed these cells to be the most potent source of tumor necrosis factor and other pro-inflammatory mediators in the obstructed kidney. F4/80(+) dendritic cells and T-cells co-localized in the cortico-medullary junction and cortex of the obstructed kidney. Cytokine secretion patterns and surface phenotypes of T-cells from obstructed kidneys were found to include interferon-gamma-secreting CD4(+) and CD8(+) memory T-cells a"],"journal":["Kidney international"],"pubmed_title":["Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction."],"pmcid":["PMC2948974"],"funding_grant_id":["D47060","R01 DK047060-10","R01 DK068545-03","DK68545","R01 DK047060","R01 DK068545"],"pubmed_authors":["Nath KA","Griffin MD","Dong X","Miller MN","Bachman LA"],"additional_accession":[]},"is_claimable":false,"name":"Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction.","description":"Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. Depletion of dendritic cells by clodronate pretreatment showed these cells to be the most potent source of tumor necrosis factor and other pro-inflammatory mediators in the obstructed kidney. F4/80(+) dendritic cells and T-cells co-localized in the cortico-medullary junction and cortex of the obstructed kidney. Cytokine secretion patterns and surface phenotypes of T-cells from obstructed kidneys were found to include interferon-gamma-secreting CD4(+) and CD8(+) memory T-cells a","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Nov","modification":"2025-04-19T09:50:02.091Z","creation":"2019-03-26T23:04:46Z"},"accession":"S-EPMC2948974","cross_references":{"pubmed":["18974760"],"doi":["10.1038/ki.2008.394"]}}