{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Guttery DS"],"funding":["Cancer Research UK","Medical Research Council"],"pubmed_abstract":["<h4>Introduction</h4>Tenascin-C (TNC) is a large extracellular matrix glycoprotein that shows prominent stromal expression in many solid tumours. The profile of isoforms expressed differs between cancers and normal breast, with the two additional domains AD1 and AD2 considered to be tumour associated. The aim of the present study was to investigate expression of AD1 and AD2 in normal, benign and malignant breast tissue to determine their relationship with tumour characteristics and to perform in vitro functional assays to investigate the role of AD1 in tumour cell invasion and growth.<h4>Methods</h4>Expression of AD1 and AD2 was related to hypoxanthine phosphoribosyltransferase 1 as a housekeeping gene in breast tissue using quantitative RT-PCR, and the results were related to clinicopatho"],"journal":["Breast cancer research : BCR"],"pagination":["R57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2949648"],"repository":["biostudies-literature"],"pubmed_title":["Association of invasion-promoting tenascin-C additional domains with breast cancers in young women."],"pmcid":["PMC2949648"],"pubmed_authors":["Mulligan KT","Hughes S","Guttery DS","Lambe SM","Shaw JA","Walker RA","Jones JL","Hancox RA","Pringle JH"],"additional_accession":[]},"is_claimable":false,"name":"Association of invasion-promoting tenascin-C additional domains with breast cancers in young women.","description":"<h4>Introduction</h4>Tenascin-C (TNC) is a large extracellular matrix glycoprotein that shows prominent stromal expression in many solid tumours. The profile of isoforms expressed differs between cancers and normal breast, with the two additional domains AD1 and AD2 considered to be tumour associated. The aim of the present study was to investigate expression of AD1 and AD2 in normal, benign and malignant breast tissue to determine their relationship with tumour characteristics and to perform in vitro functional assays to investigate the role of AD1 in tumour cell invasion and growth.<h4>Methods</h4>Expression of AD1 and AD2 was related to hypoxanthine phosphoribosyltransferase 1 as a housekeeping gene in breast tissue using quantitative RT-PCR, and the results were related to clinicopatho","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010","modification":"2026-04-14T03:21:01.273Z","creation":"2019-03-26T23:49:32Z"},"accession":"S-EPMC2949648","cross_references":{"pubmed":["20678196"],"doi":["10.1186/bcr2618"]}}