{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verzi MP"],"funding":["NIDDK NIH HHS","Crohn&apos;s and Colitis Foundation","National Institutes of Health"],"pagination":["591-600"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2955860"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(2)"],"pubmed_abstract":["<h4>Background & aims</h4>The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1.<h4>Methods</h4>We used a combination of genetic, histochemical, ultrastructural, and molecular analysis to study gastric cell lineages with respect to FOXQ1.<h4>Results</h4>Within the developing and adult gastrointestinal tract, Foxq1 messenger RNA (mRNA) is restricted to the stomach and expressed predominantly in foveolar (pit) cells, the abundant mucin-producing cells that line the mucosal s"],"journal":["Gastroenterology"],"pubmed_title":["Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells."],"pmcid":["PMC2955860"],"funding_grant_id":["R01 DK061139","T32DK07477","R01DK61139","T32 DK007477","T32 DK007533","T32DK007533"],"pubmed_authors":["Khan AH","Verzi MP","Shivdasani RA","Ito S"],"additional_accession":[]},"is_claimable":false,"name":"Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.","description":"<h4>Background & aims</h4>The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1.<h4>Methods</h4>We used a combination of genetic, histochemical, ultrastructural, and molecular analysis to study gastric cell lineages with respect to FOXQ1.<h4>Results</h4>Within the developing and adult gastrointestinal tract, Foxq1 messenger RNA (mRNA) is restricted to the stomach and expressed predominantly in foveolar (pit) cells, the abundant mucin-producing cells that line the mucosal s","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Aug","modification":"2026-05-04T04:02:29.885Z","creation":"2026-04-07T20:05:44.356Z"},"accession":"S-EPMC2955860","cross_references":{"pubmed":["18558092"],"doi":["10.1053/j.gastro.2008.04.019"]}}