biostudies-literatureVerzi MPNIDDK NIH HHSCrohn&apos;s and Colitis FoundationNational Institutes of Health591-600https://www.ebi.ac.uk/biostudies/studies/S-EPMC2955860biostudies-literatureUnknown135(2)<h4>Background & aims</h4>The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1.<h4>Methods</h4>We used a combination of genetic, histochemical, ultrastructural, and molecular analysis to study gastric cell lineages with respect to FOXQ1.<h4>Results</h4>Within the developing and adult gastrointestinal tract, Foxq1 messenger RNA (mRNA) is restricted to the stomach and expressed predominantly in foveolar (pit) cells, the abundant mucin-producing cells that line the mucosal sGastroenterologyTranscription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.PMC2955860R01 DK061139T32DK07477R01DK61139T32 DK007477T32 DK007533T32DK007533Khan AHVerzi MPShivdasani RAIto SfalseTranscription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.<h4>Background & aims</h4>The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1.<h4>Methods</h4>We used a combination of genetic, histochemical, ultrastructural, and molecular analysis to study gastric cell lineages with respect to FOXQ1.<h4>Results</h4>Within the developing and adult gastrointestinal tract, Foxq1 messenger RNA (mRNA) is restricted to the stomach and expressed predominantly in foveolar (pit) cells, the abundant mucin-producing cells that line the mucosal s2008-01-01T00:00:00Z2008 Aug2026-05-04T04:02:29.885Z2026-04-07T20:05:44.356ZS-EPMC29558601855809210.1053/j.gastro.2008.04.019