biostudies-literatureAmura CRNIDDK NIH HHSC786-96https://www.ebi.ac.uk/biostudies/studies/S-EPMC2956747biostudies-literatureUnknown294(3)Autosomal dominant polycystic kidney disease (ADPKD) is a highly prevalent genetic disease that results in cyst formation in kidney and liver. Cytokines and growth factors secreted by the cyst-lining epithelia are positioned to initiate autocrine/paracrine signaling and promote cyst growth. Comparative analyses of human kidney and liver cyst fluids revealed disparate cytokine/growth factor profiles. CXCR2 agonists, including IL-8, epithelial neutrophil-activating peptide (ENA-78), growth-related oncogene-alpha (GRO-alpha), are potent proliferative agents that were found at high levels in liver but not kidney cyst fluids. Liver cysts are lined by epithelial cells derived from the intrahepatic bile duct (i.e., cholangiocytes). In polarized pkd2(WS25/-) mouse liver cyst epithelial monolayers,American journal of physiology. Cell physiologyCXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.PMC2956747DK-034039R56 DK034039P01 DK034039Jani ALazennec GAmura CRDoctor RBGitomer BMcFann KBrodsky KSNichols MTSchrier RWfalseCXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.Autosomal dominant polycystic kidney disease (ADPKD) is a highly prevalent genetic disease that results in cyst formation in kidney and liver. Cytokines and growth factors secreted by the cyst-lining epithelia are positioned to initiate autocrine/paracrine signaling and promote cyst growth. Comparative analyses of human kidney and liver cyst fluids revealed disparate cytokine/growth factor profiles. CXCR2 agonists, including IL-8, epithelial neutrophil-activating peptide (ENA-78), growth-related oncogene-alpha (GRO-alpha), are potent proliferative agents that were found at high levels in liver but not kidney cyst fluids. Liver cysts are lined by epithelial cells derived from the intrahepatic bile duct (i.e., cholangiocytes). In polarized pkd2(WS25/-) mouse liver cyst epithelial monolayers,2008-01-01T00:00:00Z2008 Mar2025-04-05T09:57:29.657Z2019-06-06T22:25:47ZS-EPMC29567471819970310.1152/ajpcell.00457.2007