biostudies-literatureUnknown5(10)Orozco-Solis R<h4>Background</h4>Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood. However, the molecular mechanisms underlying the developmental programming of the metabolic syndrome remain largely unknown.<h4>Methodology/principal findings</h4>Given the essential role of the hypothalamus in the integration of nutritional, endocrine and neuronal cues, here we have analyzed the profile of the hypothalamus transcriptome in 180 days-old rats born to dams fed either a control (200 g/kg) or a low-protein (80 g/kg) diet through pregnancy and lactation. From a total of 26 209 examined genes, 688 were up-regulated and 309 down-regulated (P<0.003) by early protein restriction. Further bioinformatic analysis of thPloS onee13537https://www.ebi.ac.uk/biostudies/studies/S-EPMC2958833biostudies-literatureNutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus.PMC2958833Orozco-Solis RLopes de Souza SManhaes de Castro RBihouee ABolanos-Jimenez FMatos RJGuzman-Quevedo OHoulgatte RfalseNutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus.<h4>Background</h4>Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood. However, the molecular mechanisms underlying the developmental programming of the metabolic syndrome remain largely unknown.<h4>Methodology/principal findings</h4>Given the essential role of the hypothalamus in the integration of nutritional, endocrine and neuronal cues, here we have analyzed the profile of the hypothalamus transcriptome in 180 days-old rats born to dams fed either a control (200 g/kg) or a low-protein (80 g/kg) diet through pregnancy and lactation. From a total of 26 209 examined genes, 688 were up-regulated and 309 down-regulated (P<0.003) by early protein restriction. Further bioinformatic analysis of th2010-01-01T00:00:00Z2010 Oct2026-05-03T14:17:03.527Z2019-03-26T23:09:03ZS-EPMC29588332097583910.1371/journal.pone.0013537