{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu H"],"funding":["NIDA NIH HHS","NIMH NIH HHS","NCI NIH HHS"],"pagination":["18161-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2964235"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(42)"],"pubmed_abstract":["MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of neural development, including neurogenesis, dendritogenesis, and synapse formation. Rett syndrome (RTT) is a progressive neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Although Mecp2 is known to act as a global transcriptional regulator, miRNAs that are directly regulated by Mecp2 in the brain are not known. Using massively parallel sequencing methods, we have identified miRNAs whose expression is altered in cerebella of Mecp2-null mice before and after the onset of severe neurological symptoms. In vivo genome-wide analyses ind"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome."],"pmcid":["PMC2964235"],"funding_grant_id":["R03 DA022262-01","R56MH082068","R03 DA022262","R56 MH082068","RC1 CA147187","R18 MH048095","R21 MH085088","R01 MH048095"],"pubmed_authors":["Tao J","Hart RP","Ruan Y","Ruan X","Ge W","Sun YE","Chen PJ","Shahab A","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome.","description":"MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of neural development, including neurogenesis, dendritogenesis, and synapse formation. Rett syndrome (RTT) is a progressive neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Although Mecp2 is known to act as a global transcriptional regulator, miRNAs that are directly regulated by Mecp2 in the brain are not known. Using massively parallel sequencing methods, we have identified miRNAs whose expression is altered in cerebella of Mecp2-null mice before and after the onset of severe neurological symptoms. In vivo genome-wide analyses ind","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Oct","modification":"2026-05-02T08:17:04.963Z","creation":"2026-04-07T17:47:13.674Z"},"accession":"S-EPMC2964235","cross_references":{"pubmed":["20921386"],"doi":["10.1073/pnas.1005595107"]}}