biostudies-literatureIkram MKIntramural NIH HHSNEI NIH HHSNIDDK NIH HHSNCRR NIH HHSNIA NIH HHSNHLBI NIH HHSMedical Research CouncilDutch Research Council (NWO)NHGRI NIH HHSWellcome Truste1001184https://www.ebi.ac.uk/biostudies/studies/S-EPMC2965750biostudies-literatureUnknown6(10)There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 singlePLoS geneticsFour novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.PMC2965750Z01 AG007380N01 AG012100N01 HC085086R01 EY018246M01RR00069Z01 EY000401UL1 RR025005N01 HC075150ZIA EY000403ZIA EY000401R01HL087641G0801056BT32 HL007902MC_UP_A100_1003N01 HC055020N01 HC055021N01 HC055022N01 HC055222Z01 EY000403G0701863P30 DK063491DK063491M01 RR000069N01HC-55222N01-HC-55021N01-HC-55020N01-HC-75150175.010.200T32HL007902U01 HG004402N01-HC-85079N01-HC-55022U01 HL080295N01 HC055015N01 HC055016N01 HC055018ZIA EY000426N01 HC055019N01 HC035129N01-HC-55018N01-HC-55016N01-HC-85086N01-HC-55015R01 HL087652N01-HC-55019N01 HC015103G0801056UL1RR025005Z01 EY000426U01HG004402G0401527N01 HC085079MC_U105630924N01 HC045133R01 HL087641Z99 EY999999Crawford GJPsaty BMAllione AMartin NGUiterwaal CSUitterlinden AGWain LVWichmann HENavis GEyheramendy SPfeufer ALuan JZhao JHWiggins KLPolidoro SYuan XHolliday EGSchwartz SMGroop LLorbeer RKathiresan SLoos RJJensen RAVineis PWatkins HScott RJMcKnight BMcArdle WLBreteler MMZeggini ELakatta EGCoin LCollins FSAltshuler DJackson AUMatullo GHartikainen ALScheet PKhaw KTMunroe PBEiriksdottir GAspelund TSmith AVWang JJTaylor KDKlein RReffelmann TBonnycastle LLNumans MERivadeneira FVolker UPanico SIslam FMKuusisto JDominiczak ABis JCBoehnke MVollenweider PJousilahti PLathrop GMPapadakis KMohlke KLPerola MRotter JIIyengar SKOrho-Melander MPouta ARomanazzi VSanna SHercberg SHammond CJSyvanen ACDoring ASubirana IYoung TLGieger CFahy SOnland-Moret NCvan Duijn CMJarvelin MRLi XSamani NJAndrew TWallace Cvan Gilst WHMacgregor SLumley TSacerdote CJohnson TIllig TLiew GNajjar SSde Jong PEGlobal BPgen ConsortiumFreimer NBBingham SAStringham HMKooner JSHomuth GO'Donnell CJGrobbee DEWilliams FMSnieder Hde Jong PTRicceri FKlein BELauner LJBerglund GNewton-Cheh CBergman RNMeneton PLim NMcCarthy MIZhang FVolzke HSiscovick DSMelander OGudnason VTai ESvan der Schouw YTLucas GRettig RIkram MAXueling SLaan MPeden JFGuarrera SFelix SBForouhi NGIkram MKZeleneka DXi QMcAuley AKTognoni GHarris TBNewhouse SJSivakumaran TALaakso MVoight BFBergmann STobin MDSalomaa VBochud MGalan PDeloukas PTanaka THofman AHeath SCWareham NJBurton PRGoel AElliott KSHewitt AWOrg ECheung NMitchell PValle TTHeckbert SRMarrugat JScott LJSandhu MSBeckmann JSTeumer APeltonen LMackey DAClarke RBoerwinkle EAbecasis GRElliott PGut IGFerrucci LSpector TDVingerling JRCotch MFMeitinger TBarroso IWebster JWaeber GCheng CYWong TYFarrall MSeedorf UMooser VAttia JHamsten ATuomilehto JDi Gregorio ADorr MWiller CJMorken MABots MLSong KErnst FO'Reilly PFBandinelli SLuben RNSchlessinger DJonasson FWaterworth DMSoranzo Nvan der Harst PUda MGateva VZhai GStrachan DPKao LCaulfield MSim XHadley DElosua RChambers JCBrown MGlazer NLScuteri AConnell JMNilsson PfalseFour novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single2010-01-01T00:00:00Z2010 Oct2026-05-29T12:58:42.168Z2026-04-08T04:51:18.284ZS-EPMC29657502106086310.1371/journal.pgen.1001184