biostudies-literatureSun CNIDDK NIH HHSNIGMS NIH HHSe1001178https://www.ebi.ac.uk/biostudies/studies/S-EPMC2965758biostudies-literatureUnknown6(10)The mechanistic target of rapamycin (MTOR) pathway regulates cell growth, energy homeostasis, apoptosis, and immune response. The regulatory associated protein of MTOR encoded by the RPTOR gene is a key component of this pathway. A previous survey of candidate genes found that RPTOR contains multiple SNPs with strong correlations between allele frequencies and climate variables, consistent with the action of selective pressures that vary across environments. Using data from a recent genome scan for selection signals, we honed in on a SNP (rs11868112) 26 kb upstream to the transcription start site of RPTOR that exhibits the strongest association with temperature variables. Transcription factor motif scanning and mining of recently mapped transcription factor binding sites identified a bindiPLoS geneticsAllele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations.PMC2965758U01 GM61393DK056670U01 GM061393R01 DK056670Kittler RSouthard CSun CWitonsky DBDi Rienzo AfalseAllele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations.The mechanistic target of rapamycin (MTOR) pathway regulates cell growth, energy homeostasis, apoptosis, and immune response. The regulatory associated protein of MTOR encoded by the RPTOR gene is a key component of this pathway. A previous survey of candidate genes found that RPTOR contains multiple SNPs with strong correlations between allele frequencies and climate variables, consistent with the action of selective pressures that vary across environments. Using data from a recent genome scan for selection signals, we honed in on a SNP (rs11868112) 26 kb upstream to the transcription start site of RPTOR that exhibits the strongest association with temperature variables. Transcription factor motif scanning and mining of recently mapped transcription factor binding sites identified a bindi2010-01-01T00:00:00Z2010 Oct2025-04-18T21:28:26.514Z2019-03-27T00:35:12ZS-EPMC29657582106080810.1371/journal.pgen.1001178