{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu H"],"funding":["NIAID NIH HHS","NINDS NIH HHS"],"pagination":["e13780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2967469"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(11)"],"pubmed_abstract":["MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice. The MS4A family includes CD20, FcεRIβ, HTm4 and at least 26 novel members that are characterized by their structural features: with four membrane-spanning domains, two extracellular domains and two cytoplasmic regions. CD20, FcεRIβ and HTm4 have been found to function in B cells, mast cells and hematopoietic cells respectively. However, little is known about the function of MS4a4B in T cell regulation. We demonstrate here that MS4a4B negatively regulates mouse T cell proliferation. MS4a4B is highly expressed in primary T cells, natural killer cells (NK) and some T cell lines. But its expression in all malignant T cells, including thymoma and T hybridoma tested, was silenced. Interestingly, its expressio"],"journal":["PloS one"],"pubmed_title":["MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle."],"pmcid":["PMC2967469"],"funding_grant_id":["R01 NS040085","NS040085","R01 AI070823"],"pubmed_authors":["Zhang GX","Li H","Yang J","Rostami A","Williams MS","Carey GB","Xu H","Yan Y"],"additional_accession":[]},"is_claimable":false,"name":"MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.","description":"MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice. The MS4A family includes CD20, FcεRIβ, HTm4 and at least 26 novel members that are characterized by their structural features: with four membrane-spanning domains, two extracellular domains and two cytoplasmic regions. CD20, FcεRIβ and HTm4 have been found to function in B cells, mast cells and hematopoietic cells respectively. However, little is known about the function of MS4a4B in T cell regulation. We demonstrate here that MS4a4B negatively regulates mouse T cell proliferation. MS4a4B is highly expressed in primary T cells, natural killer cells (NK) and some T cell lines. But its expression in all malignant T cells, including thymoma and T hybridoma tested, was silenced. Interestingly, its expressio","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Nov","modification":"2025-04-05T13:40:13.512Z","creation":"2019-03-26T23:10:24Z"},"accession":"S-EPMC2967469","cross_references":{"pubmed":["21072172"],"doi":["10.1371/journal.pone.0013780"]}}