biostudies-literatureXu HNIAID NIH HHSNINDS NIH HHSe13780https://www.ebi.ac.uk/biostudies/studies/S-EPMC2967469biostudies-literatureUnknown5(11)MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice. The MS4A family includes CD20, FcεRIβ, HTm4 and at least 26 novel members that are characterized by their structural features: with four membrane-spanning domains, two extracellular domains and two cytoplasmic regions. CD20, FcεRIβ and HTm4 have been found to function in B cells, mast cells and hematopoietic cells respectively. However, little is known about the function of MS4a4B in T cell regulation. We demonstrate here that MS4a4B negatively regulates mouse T cell proliferation. MS4a4B is highly expressed in primary T cells, natural killer cells (NK) and some T cell lines. But its expression in all malignant T cells, including thymoma and T hybridoma tested, was silenced. Interestingly, its expressioPloS oneMS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.PMC2967469R01 NS040085NS040085R01 AI070823Zhang GXLi HYang JRostami AWilliams MSCarey GBXu HYan YfalseMS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice. The MS4A family includes CD20, FcεRIβ, HTm4 and at least 26 novel members that are characterized by their structural features: with four membrane-spanning domains, two extracellular domains and two cytoplasmic regions. CD20, FcεRIβ and HTm4 have been found to function in B cells, mast cells and hematopoietic cells respectively. However, little is known about the function of MS4a4B in T cell regulation. We demonstrate here that MS4a4B negatively regulates mouse T cell proliferation. MS4a4B is highly expressed in primary T cells, natural killer cells (NK) and some T cell lines. But its expression in all malignant T cells, including thymoma and T hybridoma tested, was silenced. Interestingly, its expressio2010-01-01T00:00:00Z2010 Nov2025-04-05T13:40:13.512Z2019-03-26T23:10:24ZS-EPMC29674692107217210.1371/journal.pone.0013780