{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kagina BM"],"funding":["NIAID NIH HHS"],"pagination":["1073-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2970848"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["182(8)"],"pubmed_abstract":["<h4>Rationale</h4>Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells.<h4>Objectives</h4>We tested whether this outcome correlates with protection against childhood TB disease after newborn vaccination with bacillus Calmette-Guérin (BCG).<h4>Methods</h4>Whole blood from 10-week-old infants, routinely vaccinated with BCG at birth, was incubated with BCG for 12 hours, followed by cryopreservation for intracellular cytokine analysis. Infants were followed for 2 years to identify those who developed culture-positive TB-these infants were regarded as not protected against TB. Infants who did not develop TB disease despite exposure to TB in the household, and another group of randomly selected infants who wer"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns."],"pmcid":["PMC2970848"],"funding_grant_id":["R01-AI065653"],"pubmed_authors":["Hanekom WA","Gamieldien H","Gelderbloem S","Hatherill M","Kagina BM","Hawkridge A","Hussey G","Soares A","Keyser A","Hughes EJ","Sidibana M","Mahomed H","Abel B","Kaplan G","Scriba TJ","other members of the South African Tuberculosis Vaccine Initiative"],"additional_accession":[]},"is_claimable":false,"name":"Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns.","description":"<h4>Rationale</h4>Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells.<h4>Objectives</h4>We tested whether this outcome correlates with protection against childhood TB disease after newborn vaccination with bacillus Calmette-Guérin (BCG).<h4>Methods</h4>Whole blood from 10-week-old infants, routinely vaccinated with BCG at birth, was incubated with BCG for 12 hours, followed by cryopreservation for intracellular cytokine analysis. Infants were followed for 2 years to identify those who developed culture-positive TB-these infants were regarded as not protected against TB. Infants who did not develop TB disease despite exposure to TB in the household, and another group of randomly selected infants who wer","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Oct","modification":"2025-04-05T14:30:09.533Z","creation":"2019-03-27T00:36:15Z"},"accession":"S-EPMC2970848","cross_references":{"pubmed":["20558627"],"doi":["10.1164/rccm.201003-0334OC","10.1164/rccm.201003-0334oc"]}}