{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin MP"],"funding":["Intramural NIH HHS","NICHD NIH HHS","NCRR NIH HHS","NIDA NIH HHS","NIAID NIH HHS","NCI NIH HHS"],"pagination":["1749-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2974014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["202(11)"],"pubmed_abstract":["An IL28B haplotype strongly determines the outcome of natural and interferon-α treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-α responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV."],"journal":["The Journal of infectious diseases"],"pubmed_title":["IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection."],"pmcid":["PMC2974014"],"funding_grant_id":["M01 RR000071","MO1-RR00071","N02CP55504","R01 DA004334","M01 RR002558","UO1-AI-37984","U01 AI037984","R01-DA-04334","U01 AI035041","U01 AI035040","MO1-RR02558","U01 AI035043","U01 AI035042","U01 AI035041-17","R01-DA-12568","U01 AI035043-17","R01-HD-4-1224","M01 RR000059","U01 AI035042-09","R56 DA004334","MO1-RR00059","MO1-RR06020","R01 HD041224-04","U01 AI037613","U01 AI035039","U01 AI037613-08","R01 DA012568","R01 DA004334-25","UO1-AI-37613","5-MO1-RR-00722","UO1-AI-35039","R01 DA012568-08","N01CO12400","UO1-AI-35040","N01-HD-4-3200","UO1-AI-35043","U01 AI035040-16","M01 RR000722","UO1-AI-35041","N01-CO-12400","U01 AI035039-19","UO1-AI-35042","K07 CA140360"],"pubmed_authors":["Kirk GD","Thio CL","Martin MP","Hoots WK","Goedert JJ","Qi Y","Buchbinder S","Carrington M","Hussain SK"],"additional_accession":[]},"is_claimable":false,"name":"IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection.","description":"An IL28B haplotype strongly determines the outcome of natural and interferon-α treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-α responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2024-11-20T05:51:22.35Z","creation":"2019-03-27T00:36:23Z"},"accession":"S-EPMC2974014","cross_references":{"pubmed":["20977343"],"doi":["10.1086/657146"]}}