biostudies-literatureUnknown5(11)Aguilar-Morante D<h4>Background</h4>Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), on murine GL261 cells growth in vitro and on the growth of established intracerebral murine gliomas in vivo.<h4>Methodology/principal findings</h4>Our data show that TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Also, we observed a sustained activation of the ERK PloS onee13879https://www.ebi.ac.uk/biostudies/studies/S-EPMC2975629biostudies-literatureInhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.PMC2975629Santos AGarcia-Cabezas MAAguilar-Morante DSanz-SanCristobal MPerez-Castillo AMorales-Garcia JAfalseInhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.<h4>Background</h4>Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), on murine GL261 cells growth in vitro and on the growth of established intracerebral murine gliomas in vivo.<h4>Methodology/principal findings</h4>Our data show that TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Also, we observed a sustained activation of the ERK 2010-01-01T00:00:00Z2010 Nov2025-04-05T14:45:34.694Z2019-03-26T23:09:05ZS-EPMC29756292107972810.1371/journal.pone.0013879