{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(22)"],"submitter":["D'Alessandra Y"],"pubmed_abstract":["<h4>Aims</h4>Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.<h4>Methods and results</h4>Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min after the onset of MI symptoms and after coronary reperfusion with percutaneous coronary intervention (PCI); miR-1, -133a, -133b, and -499-5p were ~15- to 140-fold control, whereas miR-122 and -375 were ~87-90% lower than control; 5 days later, miR-1, -133a, -133b, -499-5p, and -375 were back to baseline, whereas miR-122 remained lower than control through Day 30. In additional patients ("],"journal":["European heart journal"],"pagination":["2765-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2980809"],"repository":["biostudies-literature"],"pubmed_title":["Circulating microRNAs are new and sensitive biomarkers of myocardial infarction."],"pmcid":["PMC2980809"],"pubmed_authors":["Achilli F","Di Carlo A","Maggiolini S","Carena MC","Biglioli P","Straino S","Devanna P","Spazzafumo L","Micheli B","Capogrossi MC","Marenzi G","D'Alessandra Y","Rubino M","Limana F","Martelli F","Pompilio G","De Simone M","Brambilla PG"],"additional_accession":[]},"is_claimable":false,"name":"Circulating microRNAs are new and sensitive biomarkers of myocardial infarction.","description":"<h4>Aims</h4>Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.<h4>Methods and results</h4>Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min after the onset of MI symptoms and after coronary reperfusion with percutaneous coronary intervention (PCI); miR-1, -133a, -133b, and -499-5p were ~15- to 140-fold control, whereas miR-122 and -375 were ~87-90% lower than control; 5 days later, miR-1, -133a, -133b, -499-5p, and -375 were back to baseline, whereas miR-122 remained lower than control through Day 30. In additional patients (","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Nov","modification":"2026-07-15T10:07:21.654Z","creation":"2026-07-03T03:12:02.358Z"},"accession":"S-EPMC2980809","cross_references":{"pubmed":["20534597"],"doi":["10.1093/eurheartj/ehq167"]}}