biostudies-literatureUnknown31(22)D'Alessandra Y<h4>Aims</h4>Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.<h4>Methods and results</h4>Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min after the onset of MI symptoms and after coronary reperfusion with percutaneous coronary intervention (PCI); miR-1, -133a, -133b, and -499-5p were ~15- to 140-fold control, whereas miR-122 and -375 were ~87-90% lower than control; 5 days later, miR-1, -133a, -133b, -499-5p, and -375 were back to baseline, whereas miR-122 remained lower than control through Day 30. In additional patients (European heart journal2765-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC2980809biostudies-literatureCirculating microRNAs are new and sensitive biomarkers of myocardial infarction.PMC2980809Achilli FDi Carlo AMaggiolini SCarena MCBiglioli PStraino SDevanna PSpazzafumo LMicheli BCapogrossi MCMarenzi GD'Alessandra YRubino MLimana FMartelli FPompilio GDe Simone MBrambilla PGfalseCirculating microRNAs are new and sensitive biomarkers of myocardial infarction.<h4>Aims</h4>Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.<h4>Methods and results</h4>Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min after the onset of MI symptoms and after coronary reperfusion with percutaneous coronary intervention (PCI); miR-1, -133a, -133b, and -499-5p were ~15- to 140-fold control, whereas miR-122 and -375 were ~87-90% lower than control; 5 days later, miR-1, -133a, -133b, -499-5p, and -375 were back to baseline, whereas miR-122 remained lower than control through Day 30. In additional patients (2010-01-01T00:00:00Z2010 Nov2026-07-15T10:07:21.654Z2026-07-03T03:12:02.358ZS-EPMC29808092053459710.1093/eurheartj/ehq167