biostudies-literatureUnknown29(1)Ponomarenko JVACTIVITY is a database on DNA/RNA site sequences with known activity magnitudes, measurement systems, sequence-activity relationships under fixed experimental conditions and procedures to adapt these relationships from one measurement system to another. This database deposits information on DNA/RNA affinities to proteins and cell nuclear extracts, cutting efficiencies, gene transcription activity, mRNA translation efficiencies, mutability and other biological activities of natural sites occurring within promoters, mRNA leaders, and other regulatory regions in pro- and eukaryotic genomes, their mutant forms and synthetic analogues. Since activity magnitudes are heavily system-dependent, the current version of ACTIVITY is supplemented by three novel sub-databases: (i) SYSTEM, measurement sysNucleic acids research284-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC29829biostudies-literatureACTIVITY: a database on DNA/RNA sites activity adapted to apply sequence-activity relationships from one system to another.PMC29829Podkolodny NLSarai AOrlova GVPonomarenko JVKolchanov NAFurman DPFrolov ASPonomarenko MPfalseACTIVITY: a database on DNA/RNA sites activity adapted to apply sequence-activity relationships from one system to another.ACTIVITY is a database on DNA/RNA site sequences with known activity magnitudes, measurement systems, sequence-activity relationships under fixed experimental conditions and procedures to adapt these relationships from one measurement system to another. This database deposits information on DNA/RNA affinities to proteins and cell nuclear extracts, cutting efficiencies, gene transcription activity, mRNA translation efficiencies, mutability and other biological activities of natural sites occurring within promoters, mRNA leaders, and other regulatory regions in pro- and eukaryotic genomes, their mutant forms and synthetic analogues. Since activity magnitudes are heavily system-dependent, the current version of ACTIVITY is supplemented by three novel sub-databases: (i) SYSTEM, measurement sys2001-01-01T00:00:00Z2001 Jan2025-04-04T19:17:44.716Z2019-03-27T00:17:56ZS-EPMC298291112511410.1093/nar/29.1.284