{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(4)"],"submitter":["Moonesinghe R"],"pubmed_abstract":["Genetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the "],"journal":["European journal of human genetics : EJHG"],"pagination":["485-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2987256"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases."],"pmcid":["PMC2987256"],"pubmed_authors":["Moonesinghe R","Liu T","Khoury MJ"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases.","description":"Genetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2025-04-18T21:26:20.635Z","creation":"2019-08-04T07:52:11Z"},"accession":"S-EPMC2987256","cross_references":{"pubmed":["19935832"],"doi":["10.1038/ejhg.2009.209"]}}