biostudies-literatureUnknown18(4)Moonesinghe RGenetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the European journal of human genetics : EJHG485-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC2987256biostudies-literatureEvaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases.PMC2987256Moonesinghe RLiu TKhoury MJfalseEvaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases.Genetic testing for susceptibility to common diseases based on a combination of genetic markers may be needed because the effect size associated with each genetic marker is small. Whether or not a genome profile based on a combination of markers could yield a useful test can be evaluated by assessing the discriminative accuracy. The authors present a simple method to calculate the clinical discriminative accuracy of a genomic profile when the relative risk and genotype frequency of each genotype are known. In addition, the clinical discriminative accuracy of a genetic test is presented for given values of the heritability and prevalence of the disease and for the population-attributable fraction of the combined genetic markers. For given values of relative risk and genotype frequency, the 2010-01-01T00:00:00Z2010 Apr2025-04-18T21:26:20.635Z2019-08-04T07:52:11ZS-EPMC29872561993583210.1038/ejhg.2009.209